Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid

Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid

Core binding factor β (Cbfb) is a cofactor of the Runx family of transcription factors. Among these transcription factors, Runx1 is a prerequisite for anterior-specific palatal fusion. It was previously unclear, however, whether Cbfb served as a modulator or as an obligatory factor in the Runx signa...

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Bibliographic Details
Main Authors: Safiye E. Sarper, Toshihiro Inubushi, Hiroshi Kurosaka, Hitomi Ono Minagi, Yuka Murata, Koh-ichi Kuremoto, Takayoshi Sakai, Ichiro Taniuchi, Takashi Yamashiro
Format: Article
Language:English
Published: The Company of Biologists 2019-06-01
Series:Disease Models & Mechanisms
Subjects:
Stat3
Palatogenesis
Palatal fusion
Epithelial disintegration
Runx transcription factors
Tgfb
Online Access:http://dmm.biologists.org/content/12/6/dmm038851

Internet

http://dmm.biologists.org/content/12/6/dmm038851

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