Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways.

Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways.

Protein phosphorylation homoeostasis is tightly controlled and pathological conditions are caused by subtle alterations of the cell phosphorylation profile. Altered levels of kinase activities have already been associated to specific diseases. Less is known about the impact of phosphatases, the enzy...

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Bibliographic Details
Main Authors: Francesca eSacco, Karsten eBoldt, Alberto eCalderone, Simona ePanni, Serena ePaoluzi, Luisa eCastagnoli, Marius eUeffing, Gianni eCesareni
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Genetics
Subjects:
Cell Biology
Signal Transduction
Systems Biology
protein protein interaction
phosphatase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00115/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00115/full

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