The Toxoplasma gondii ME-49 strain upregulates levels of A20 that inhibit NF-κB activation and promotes apoptosis in human leukaemia T-cell lines

The Toxoplasma gondii ME-49 strain upregulates levels of A20 that inhibit NF-κB activation and promotes apoptosis in human leukaemia T-cell lines

Abstract Background Acute T-lymphocyte leukaemia is a form of haematological malignancy with abnormal activation of NF-κB pathway, which results in high expression of A20 and ABIN1, which constitute a negative feedback mechanism for the regulation of NF-κB activation. Clinical studies have found tha...

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Bibliographic Details
Main Authors: Qian Chen, Min-Hui Pang, Xiao-Hong Ye, Guang Yang, Chen Lin
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Parasites & Vectors
Subjects:
Toxoplasma gondii ME-49 strain
A20
ABIN1
Human leukaemia T-cells
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13071-018-2837-1

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http://link.springer.com/article/10.1186/s13071-018-2837-1

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