Beautiful small: Misleading large randomized controlled trials? The example of colloids for volume resuscitation

Beautiful small: Misleading large randomized controlled trials? The example of colloids for volume resuscitation

In anesthesia and intensive care, treatment benefits that were claimed on the basis of small or modest-sized trials have repeatedly failed to be confirmed in large randomized controlled trials. A well-designed small trial in a homogeneous patient population with high event rates could yield conclusi...

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Bibliographic Details
Main Authors: Christian J Wiedermann, Wolfgang Wiedermann
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Journal of Anaesthesiology Clinical Pharmacology
Subjects:
Bias
consistency
design
meta-analysis
randomized controlled trial
sample size determination
Online Access:http://www.joacp.org/article.asp?issn=0970-9185;year=2015;volume=31;issue=3;spage=394;epage=400;aulast=Wiedermann

Internet

http://www.joacp.org/article.asp?issn=0970-9185;year=2015;volume=31;issue=3;spage=394;epage=400;aulast=Wiedermann

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