Minimally disruptive optical control of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its native cellular organization.

Bibliographic Details
Main Authors: Akarawin Hongdusit, Peter H. Zwart, Banumathi Sankaran, Jerome M. Fox
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14567-8