Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series

Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series

IntroductionCurrent drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective pharma...

Full description

Bibliographic Details
Main Authors: Jarinda A. Poppe, Willem van Weteringen, Lotte L. G. Sebek, Catherijne A. J. Knibbe, Irwin K. M. Reiss, Sinno H. P. Simons, Robert B. Flint
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
precision dosing
doxapram
pharmacokinetic modelling
pharmacodynamics
preterm infants
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00665/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00665/full

Similar Items