Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice

Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice

Immune rejection after transplantation is common, which leads to prompt failure of the graft. Therefore, to prolong the survival time of the graft, immunosuppressive therapy is the norm. Here, we report a robust immune protection protocol using FK506-loaded microspheres (FK506M) in injectable hydrog...

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Bibliographic Details
Main Authors: Shiva Pathak, Shobha Regmi, Biki Gupta, Bijay K. Poudel, Tung Thanh Pham, Chul Soon Yong, Jong Oh Kim, Jae-Ryong Kim, Min Hui Park, Young Kyung Bae, Simmyung Yook, Cheol-Hee Ahn, Jee-Heon Jeong
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
electrospray
fk506
microspheres
islet transplantation
immune suppression
Online Access:http://dx.doi.org/10.1080/10717544.2017.1377317

Internet

http://dx.doi.org/10.1080/10717544.2017.1377317

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