Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation

Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation

Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage differentiation protocols exist, with phorbol 12-myristate-13-acetate (PMA) be...

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Bibliographic Details
Main Authors: Sneha M. Pinto, Hera Kim, Yashwanth Subbannayya, Miriam S. Giambelluca, Korbinian Bösl, Liv Ryan, Animesh Sharma, Richard K. Kandasamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
monocyte
macrophage
TLR signaling
innate immune signaling
functional networks
pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.679458/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.679458/full

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