Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis

Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis

Background: In the human central nervous system (CN), resting astrocytes do not visually show endothelin-1 (ET-1)-like immunoreactivity. In patients with multiple sclerosis (MS), an inflammatory disorder of the CNS, high levels of ET-1 are found in reactive astrocytes in demyelinated plaques. ET-1 m...

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Bibliographic Details
Main Authors: Stéphanie Hostenbach, Miguel D’Haeseleer, Ron Kooijman, Jacques De Keyser
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
multiple sclerosis
endothelin-1
astrocytes
cytokines
inflammation
fluoxetine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01491/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01491/full

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