Clinical association of progesterone receptor isoform A with breast cancer metastasis consistent with its unique mechanistic role in preclinical models

Clinical association of progesterone receptor isoform A with breast cancer metastasis consistent with its unique mechanistic role in preclinical models

Abstract Background Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the progesterone receptor (PR). Invasiveness and metastasis of L-BCa cells is sup...

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Bibliographic Details
Main Authors: Rayna Rosati, Kailey Oppat, Yanfang Huang, Seongho Kim, Manohar Ratnam
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
Breast cancer
Progesterone receptor
Estrogen receptor
Estrogen
Progesterone
Mifepristone
Online Access:http://link.springer.com/article/10.1186/s12885-020-07002-0

Internet

http://link.springer.com/article/10.1186/s12885-020-07002-0

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