Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

<p>Abstract</p> <p>Background</p> <p>Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD<sub>50 </sub>of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. T...

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Bibliographic Details
Main Authors: Pierson Janice, Brochu Eric, Neveu Nathalie, Bégin Isabelle, Herskovits Peter, Touati Madjid, Brouillard Sandra, Bilodeau Annie S, Bellemare Annie, Côté Mélanie, Turcotte Carl, Wang Bin, Baldassarre Hernan, Huang Yue, Lazaris Anthoula, Lundy Paul M, Huang Yue-Jin, Hockley Duncan K, Cerasoli Douglas M, Lenz David E, Wilgus Harvey, Karatzas Costas N, Langermann Solomon
Format: Article
Language:English
Published: BMC 2008-05-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/8/50

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http://www.biomedcentral.com/1472-6750/8/50

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