A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level

A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level

Abstract Background To determine if the rs7079 polymorphism located in the 3′ UTR of the angiotensinogen gene (AGT) altered AGT gene expression and the risk of lead poisoning. A case-control study and luciferase reporter gene assay identified a significant association between rs7079 variants and the...

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Bibliographic Details
Main Authors: Yu Wu, Miaomiao Wang, Jinlong Zhang, Na Sun, Chunping Li
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Hereditas
Subjects:
Lead poisoning
3′ untranslated region (3′ UTR)
SNP
miRNA
AGT
Online Access:http://link.springer.com/article/10.1186/s41065-019-0084-x

Internet

http://link.springer.com/article/10.1186/s41065-019-0084-x

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