Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

Loss-of-function mutations of NaV1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of NaV1.7 a promising therapeutic strategy for the treatment of pain. We charact...

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Bibliographic Details
Main Authors: Jennifer R. Deuis, Joshua S. Wingerd, Zoltan Winter, Thomas Durek, Zoltan Dekan, Silmara R. Sousa, Katharina Zimmermann, Tali Hoffmann, Christian Weidner, Mohammed A. Nassar, Paul F. Alewood, Richard J. Lewis, Irina Vetter
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Toxins
Subjects:
OD1
NaV1.7
PF-04856264
CNV1014802
raxatrigine
GpTx-1
pain
Online Access:http://www.mdpi.com/2072-6651/8/3/78

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http://www.mdpi.com/2072-6651/8/3/78

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