Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model

Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model

Abstract Background Lipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative conditions. Interestingly, both neuroprotective and neurodegenerative effects have been described for Lcn2. Increased Lcn2 levels were found in human post-mortem Alzheimer (AD) brain tissue, and...

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Bibliographic Details
Main Authors: Doortje W. Dekens, Petrus J. W. Naudé, Jan N. Keijser, Ate S. Boerema, Peter P. De Deyn, Ulrich L. M. Eisel
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Lipocalin 2
Neutrophil gelatinase-associated lipocalin (NGAL)
Neuroinflammation
Astrocytes
Memory
Online Access:http://link.springer.com/article/10.1186/s12974-018-1372-5

Internet

http://link.springer.com/article/10.1186/s12974-018-1372-5

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