Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with a crude mortality rate of ~35%. Previously, we established a human DPP4 transgenic (hDPP4-Tg) mouse model in which we studied complement overactivation-induced immunopathogenesis. Here, to better understand the...

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Bibliographic Details
Main Authors: Yuting Jiang, Junfeng Li, Yue Teng, Hong Sun, Guang Tian, Lei He, Pei Li, Yuehong Chen, Yan Guo, Jiangfan Li, Guangyu Zhao, Yusen Zhou, Shihui Sun
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Viruses
Subjects:
MERS-CoV
inflammation
pyroptosis
complement
Online Access:http://www.mdpi.com/1999-4915/11/1/39

Internet

http://www.mdpi.com/1999-4915/11/1/39

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