Lipophosphoglycans from Leishmania amazonensis Strains Display Immunomodulatory Properties via TLR4 and Do Not Affect Sand Fly Infection.

The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species...

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Main Authors: Paula M Nogueira, Rafael R Assis, Ana C Torrecilhas, Elvira M Saraiva, Natália L Pessoa, Marco A Campos, Eric F Marialva, Cláudia M Ríos-Velasquez, Felipe A Pessoa, Nágila F Secundino, Jerônimo N Rugani, Elsa Nieves, Salvatore J Turco, Maria N Melo, Rodrigo P Soares
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4980043?pdf=render