Label-Free Quantitative Proteomics Combined with Biological Validation Reveals Activation of Wnt/β-Catenin Pathway Contributing to Trastuzumab Resistance in Gastric Cancer

Label-Free Quantitative Proteomics Combined with Biological Validation Reveals Activation of Wnt/β-Catenin Pathway Contributing to Trastuzumab Resistance in Gastric Cancer

Resistance to trastuzumab, which specifically target HER2-positive breast and gastric cancer, can develop ultimately in cancer patients. However, the underlying mechanisms of resistance in gastric cancer have not been fully elucidated. Here, we established trastuzumab-resistant MKN45 and NCI N87 gas...

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Bibliographic Details
Main Authors: Wenhu Liu, Jiangbei Yuan, Zhenzhong Liu, Jianwu Zhang, Jinxia Chang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
gastric cancer
trastuzumab resistance
Wnt/β-catenin pathway
EMT
label-free quantitative proteomics
Online Access:http://www.mdpi.com/1422-0067/19/7/1981

Internet

http://www.mdpi.com/1422-0067/19/7/1981

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