The molecular basis of ceramide-1-phosphate recognition by C2 domains[S]

Group IVA cytosolic phospholipase A2 (cPLA2α), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. The C2 domain has been shown to bind zwitterionic lipids, but more r...

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Bibliographic Details
Main Authors: Katherine E. Ward, Nitin Bhardwaj, Mohsin Vora, Charles E. Chalfant, Hui Lu, Robert V. Stahelin
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520419297