S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy

S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy

Loss of skeletal muscle mass and force aggravates age-related sarcopenia and numerous pathologies, such as cancer and diabetes. The AKT-mTORC1 pathway plays a major role in stimulating adult muscle growth; however, the functional role of its downstream mediators in vivo is unknown. Here, we show tha...

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Bibliographic Details
Main Authors: Manuela Marabita, Martina Baraldo, Francesca Solagna, Judith Johanna Maria Ceelen, Roberta Sartori, Hendrik Nolte, Ivan Nemazanyy, Stéphane Pyronnet, Marcus Kruger, Mario Pende, Bert Blaauw
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
skeletal muscle
hypertrophy
AKT
S6K1
rapamycin
p62
protein aggregates
muscle force
mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312426

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http://www.sciencedirect.com/science/article/pii/S2211124716312426

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