Differential role of SIRT1/MAPK pathway during cerebral ischemia in rats and humans

Abstract Cerebral ischemia (CI) is a severe cause of neurological dysfunction and mortality. Sirtuin-1 (Silent information regulator family protein 1, SIRT1), an oxidized nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase, plays an important role in protection against several neu...

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Bibliographic Details
Main Authors: Sireesh Kumar Teertam, Phanithi Prakash Babu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85577-9