Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model

Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model

Studies demonstrated that spinal autophagy was impaired in spinal nerve ligation (SNL) rats. However, the relationship of endoplasmic reticulum (ER) stress and ER-phagy and whether dexmedetomidine (DEX) modulates ER-phagy remain unclear. In this study, male Sprague–Dawley (SD) rats and the SNL anima...

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Bibliographic Details
Main Authors: Yongda Liu, Shuang Wang, Zhibin Wang, Mengmeng Ding, Xingyue Li, Jiao Guo, Guang Han, Ping Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Neuroscience
Subjects:
ER stress
autophagy
ER-phagy
neuropathic pain
spinal cord
dexmedetomidine
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00090/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00090/full

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