Filociclovir Is an Active Antiviral Agent against Ocular Adenovirus Isolates In Vitro and in the Ad5/NZW Rabbit Ocular Model

Filociclovir Is an Active Antiviral Agent against Ocular Adenovirus Isolates In Vitro and in the Ad5/NZW Rabbit Ocular Model

Presently, there is no FDA- or EMA-approved antiviral for the treatment of human adenovirus (HAdV) ocular infections. This study determined the antiviral activity of filociclovir (FCV) against ocular HAdV isolates in vitro and in the Ad5/NZW rabbit ocular model. The 50% effective concentrations (EC&...

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Bibliographic Details
Main Authors: Eric G. Romanowski, Islam T. M. Hussein, Steven C. Cardinale, Michelle M. Butler, Lucas R. Morin, Terry L. Bowlin, Kathleen A. Yates, Robert M. Q. Shanks, Regis P. Kowalski
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
filociclovir
antiviral
eye
adenovirus
EKC
in vitro
Online Access:https://www.mdpi.com/1424-8247/14/4/294

Internet

https://www.mdpi.com/1424-8247/14/4/294

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