Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

Abstract Background Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studies, the high-throughput short-read sequencing largely ignores the epige...

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Bibliographic Details
Main Authors: Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li, Chong Tang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Epigenetics & Chromatin
Subjects:
ecDNA
Chromatin accessibility
Methylation
m6A
Methyltransferase
Online Access:https://doi.org/10.1186/s13072-021-00416-5

Internet

https://doi.org/10.1186/s13072-021-00416-5

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