Cancer chemotherapy: targeting folic acid synthesis
Nicole Hagner, Markus JoergerDepartment of Medical Oncology, Cantonal Hospital, St Gallen, SwitzerlandAbstract: Antifolates are structural analogs of folates, essential one-carbon donors in the synthesis of DNA in mammalian cells. Antifolates are inhibitors of key enzymes in folate metabolism, namel...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2010-11-01
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| Series: | Cancer Management and Research |
| Online Access: | http://www.dovepress.com/cancer-chemotherapy-targeting-folic-acid-synthesis-a5698 |