Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ

Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ

Cytokine gene delivery by viral vectors is a promising novel strategy for cancer immunotherapy. Semliki Forest virus (SFV) has many advantages as a delivery vector, including the ability to (i) induce p53-independent killing of tumor cells via apoptosis, (ii) elicit a type-I interferon (IFN) respons...

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Bibliographic Details
Main Authors: Baiba Kurena, Elisabeth Müller, Panagiotis F. Christopoulos, Ingvild Bjellmo Johnsen, Branislava Stankovic, Inger Øynebråten, Alexandre Corthay, Anna Zajakina
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
Semliki Forest virus
cancer immunotherapy
gene delivery
cytokines
macrophage activation
Lewis lung carcinoma
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01667/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01667/full

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