Neuroprotective effect of Notch pathway inhibitor DAPT against focal cerebral ischemia/reperfusion 3 hours before model establishment

Neuroprotective effect of Notch pathway inhibitor DAPT against focal cerebral ischemia/reperfusion 3 hours before model establishment

As an inhibitor of the Notch signaling pathway, N-[N-(3,5-difluorohenacetyl)-l-alanyl]-S-phenylglycine tert-butyl ester (DAPT) may protect brain tissue from serious ischemic injury. This study aimed to explore neuroprotection by DAPT after cerebral ischemia/reperfusion (I/R) injury. DAPT was intrape...

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Bibliographic Details
Main Authors: Jun-Jie Wang, Jun-De Zhu, Xian-Hu Zhang, Ting-Ting Long, Guo Ge, Yan Yu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; DAPT; cerebral ischemia; glial fibrillary acidic protein; Notch1; Hes1; Hes5; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=452;epage=461;aulast=Wang

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=452;epage=461;aulast=Wang

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