Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate

Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate

In the aorta-gonad-mesonephros (AGM) region of mouse embryos, pre-hematopoietic stem cells (pre-HSCs) are generated from rare and specialized hemogenic endothelial cells (HECs) via endothelial-to-hematopoietic transition, followed by maturation into bona fide hematopoietic stem cells (HSCs). As HECs...

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Bibliographic Details
Main Authors: Wanbo Tang, Jian He, Tao Huang, Zhijie Bai, Chaojie Wang, Haizhen Wang, Ruichuang Yang, Yanli Ni, Jun Hou, Junliang Wang, Jie Zhou, Yingpeng Yao, Yandong Gong, Siyuan Hou, Bing Liu, Yu Lan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pre-hematopoietic stem cells
hematopoietic stem cells
Hlf
aorta-gonad-mesonephros
genetic lineage tracing
hematopoietic development
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.728057/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.728057/full

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