LOcating non-unique matched tags (LONUT) to improve the detection of the enriched regions for ChIP-seq data.

LOcating non-unique matched tags (LONUT) to improve the detection of the enriched regions for ChIP-seq data.

One big limitation of computational tools for analyzing ChIP-seq data is that most of them ignore non-unique tags (NUTs) that match the human genome even though NUTs comprise up to 60% of all raw tags in ChIP-seq data. Effectively utilizing these NUTs would increase the sequencing depth and allow a...

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Bibliographic Details
Main Authors: Rui Wang, Hang-Kai Hsu, Adam Blattler, Yisong Wang, Xun Lan, Yao Wang, Pei-Yin Hsu, Yu-Wei Leu, Tim H-M Huang, Peggy J Farnham, Victor X Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3692479?pdf=render

Internet

http://europepmc.org/articles/PMC3692479?pdf=render

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