Inhibition of Autophagy Prevents Panax Notoginseng Saponins (PNS) Protection on Cardiac Myocytes Against Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Injury, Ca2+ Homeostasis and Associated Apoptosis

Inhibition of Autophagy Prevents Panax Notoginseng Saponins (PNS) Protection on Cardiac Myocytes Against Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Injury, Ca2+ Homeostasis and Associated Apoptosis

Endoplasmic reticulum (ER) stress is often closely linked to autophagy, hypoxia signaling, mitochondrial biogenesis and reactive oxygen species (ROS) responses. Understanding the interaction between ER stress, mitochondrial function and autophagy is of great importance to provide new mechanisms for...

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Bibliographic Details
Main Authors: Jun Chen, Li Li, Xueyang Bai, Lili Xiao, Jiahong Shangguan, Wenjing Zhang, Xiangqin Zhang, Shen Wang, Gangqiong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
PNS
ER stress
autophagy
mitochondrial injury
ROS
RyR2 oxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.620812/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.620812/full

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