Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury

Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury

Abstract Background Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. We tested the hypothesis that preservation of tissue concentrations of...

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Bibliographic Details
Main Authors: Takashi Tani, Ken Okamoto, Megumi Fujiwara, Akira Katayama, Shuichi Tsuruoka
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Molecular Medicine
Subjects:
Metabolome
Xanthine oxidoreductase inhibitor
Ischemia-reperfusion injury
Online Access:http://link.springer.com/article/10.1186/s10020-019-0109-y

Internet

http://link.springer.com/article/10.1186/s10020-019-0109-y

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