On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study.

Testing for genetic effects on mean values of a quantitative trait has been a very successful strategy. However, most studies to date have not explored genetic effects on the variance of quantitative traits as a relevant consequence of genetic variation. In this report, we demonstrate that, under pl...

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Bibliographic Details
Main Authors: Guillaume Paré, Nancy R Cook, Paul M Ridker, Daniel I Chasman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2887471?pdf=render