Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia miltiorrhiza, has well-known antioxidant and anti...

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Bibliographic Details
Main Authors: Musen Lin, Xiaohan Zhai, Guangzhi Wang, Xiaofeng Tian, Dongyan Gao, Lei Shi, Hang Wu, Qing Fan, Jinyong Peng, Kexin Liu, Jihong Yao
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Acetaminophen hepatotoxicity
Nrf2
Phase II enzyme
PI3K
PKC
Salvianolic acid B (SalB)
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861314000310

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http://www.sciencedirect.com/science/article/pii/S1347861314000310

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