Detection of HIV-1 neutralizing antibodies in a human CD4⁺/CXCR4⁺/CCR5⁺ T-lymphoblastoid cell assay system.

Detection of HIV-1 neutralizing antibodies in a human CD4⁺/CXCR4⁺/CCR5⁺ T-lymphoblastoid cell assay system.

Sensitive assays are needed to meaningfully assess low levels of neutralizing antibodies (NAbs) that may be important for protection against the acquisition of HIV-1 infection in vaccine recipients. The current assay of choice uses a non-lymphoid cell line (TZM-bl) that may lack sensitivity owing to...

Full description

Bibliographic Details
Main Authors: Robert J McLinden, Celia C Labranche, Agnès-Laurence Chenine, Victoria R Polonis, Michael A Eller, Lindsay Wieczorek, Christina Ochsenbauer, John C Kappes, Stephen Perfetto, David C Montefiori, Nelson L Michael, Jerome H Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842913?pdf=render

Internet

http://europepmc.org/articles/PMC3842913?pdf=render

Similar Items