Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function

Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function

Acid-sensing ion channels (ASICs) act as pH sensors in neurons. ASICs contribute to pain sensation, learning, fear behavior and to neuronal death after ischemic stroke. Extracellular acidification induces a transient activation and subsequent desensitization of these Na+-selective channels. ASICs ar...

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Bibliographic Details
Main Authors: Olivier Bignucolo, Sabrina Vullo, Nicolas Ambrosio, Ivan Gautschi, Stephan Kellenberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
ion channel
current kinetics
subunit interaction
structure-function relationship
salt bridge
molecular dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00058/full

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https://www.frontiersin.org/article/10.3389/fmolb.2020.00058/full

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