β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer

Abstract Background Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1. Methods HSF1 expression was analyzed by chromatin immunoprecipitation,...

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Bibliographic Details
Main Authors: Ping Song, Lifeng Feng, Jiaqiu Li, Dongjun Dai, Liyuan Zhu, Chaoqun Wang, Jingyi Li, Ling Li, Qiyin Zhou, Rongkai Shi, Xian Wang, Hongchuan Jin
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Cancer
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12943-020-01244-z