Myricetin Possesses Anthelmintic Activity and Attenuates Hepatic Fibrosis via Modulating TGFβ1 and Akt Signaling and Shifting Th1/Th2 Balance in Schistosoma japonicum-Infected Mice

Myricetin Possesses Anthelmintic Activity and Attenuates Hepatic Fibrosis via Modulating TGFβ1 and Akt Signaling and Shifting Th1/Th2 Balance in Schistosoma japonicum-Infected Mice

Schistosomiasis is a zoonotic and debilitating parasitic disease caused by Schistosoma japonicum. Praziquantel remains the choice for treating schistosomiasis, but its efficacy could be hampered by emergence of resistance. In this study, using large-scale drug screening, we selected out myricetin, a...

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Bibliographic Details
Main Authors: Ping Huang, Minyu Zhou, Shaoyun Cheng, Yue Hu, Minzhao Gao, Yubin Ma, Yanin Limpanont, Hongli Zhou, Paron Dekumyoy, Yixin Cheng, Zhiyue Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
Schistosoma japonicum
myricetin
Th1/Th2 balance
TGFβ1/Smad
Akt
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00593/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00593/full

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