Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering.

Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering.

Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR2 with in vitro physiological and Ca2+ signaling assays to determi...

Full description

Bibliographic Details
Main Authors: Scott Boitano, Justin Hoffman, Dipti V Tillu, Marina N Asiedu, Zhenyu Zhang, Cara L Sherwood, Yan Wang, Xinzhong Dong, Theodore J Price, Josef Vagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4057235?pdf=render

Internet

http://europepmc.org/articles/PMC4057235?pdf=render

Similar Items