Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar ran...
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Instituto Oswaldo Cruz, Ministério da Saúde
2008-12-01
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| Series: | Memórias do Instituto Oswaldo Cruz. |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005 |
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doaj-f4128a8993ca4478982625dd7019505f2020-11-25T00:14:00ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80602008-12-01103877377710.1590/S0074-02762008000800005Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapiesStela R FerrariniCedric S GraebinJones LimbergerRômulo FS CantoDaiane O DiasRicardo G da RosaMaria de Fátima MadeiraVera L Eifler-LimaA series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005limoneneβ-amino alcoholsynthesisleishmaniasisLeishmania braziliensisneglected diseases |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stela R Ferrarini Cedric S Graebin Jones Limberger Rômulo FS Canto Daiane O Dias Ricardo G da Rosa Maria de Fátima Madeira Vera L Eifler-Lima |
| spellingShingle |
Stela R Ferrarini Cedric S Graebin Jones Limberger Rômulo FS Canto Daiane O Dias Ricardo G da Rosa Maria de Fátima Madeira Vera L Eifler-Lima Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies Memórias do Instituto Oswaldo Cruz. limonene β-amino alcohol synthesis leishmaniasis Leishmania braziliensis neglected diseases |
| author_facet |
Stela R Ferrarini Cedric S Graebin Jones Limberger Rômulo FS Canto Daiane O Dias Ricardo G da Rosa Maria de Fátima Madeira Vera L Eifler-Lima |
| author_sort |
Stela R Ferrarini |
| title |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_short |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_full |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_fullStr |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_full_unstemmed |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_sort |
synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
| series |
Memórias do Instituto Oswaldo Cruz. |
| issn |
0074-0276 1678-8060 |
| publishDate |
2008-12-01 |
| description |
A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives. |
| topic |
limonene β-amino alcohol synthesis leishmaniasis Leishmania braziliensis neglected diseases |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005 |
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