Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies

Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies

A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar ran...

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Bibliographic Details
Main Authors: Stela R Ferrarini, Cedric S Graebin, Jones Limberger, Rômulo FS Canto, Daiane O Dias, Ricardo G da Rosa, Maria de Fátima Madeira, Vera L Eifler-Lima
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2008-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
limonene
β-amino alcohol
synthesis
leishmaniasis
Leishmania braziliensis
neglected diseases
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005

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