Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor

Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor

Abstract Dioxoisoindolines have been included as a pharmacophore group in diverse drug-like molecules with a wide range of biological activity. Various reports have shown that phthalimide derivatives are potent inhibitors of AChE, a key enzyme involved in the deterioration of the cholinergic system...

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Bibliographic Details
Main Authors: Erik Andrade-Jorge, José Bribiesca-Carlos, Francisco J. Martínez-Martínez, Marvin A. Soriano-Ursúa, Itzia I. Padilla-Martínez, José G. Trujillo-Ferrara
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Chemistry Central Journal
Subjects:
AChE inhibitor
Alzheimer’s disease
Crystal structure
Isoindoline-1
3-Dione
Kinetic
Online Access:http://link.springer.com/article/10.1186/s13065-018-0442-1

Internet

http://link.springer.com/article/10.1186/s13065-018-0442-1

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