Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family

Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family

Homologous domains embedded in multidomain proteins of different domain architectures (DA) may exhibit subtle, but important, differences in their structure and function. Here, we consider two multidomain proteins, Arf nucleotide binding site opener (ARNO) and G protein‐coupled receptor kinase 2 (GR...

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Bibliographic Details
Main Authors: Nagarajan Naveenkumar, Ramanathan Sowdhamini, Narayanaswamy Srinivasan
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:FEBS Open Bio
Subjects:
Arf6
ARNO
GRK2
multidomain proteins
PH domain
phosphoinositide binding
Online Access:https://doi.org/10.1002/2211-5463.12725

Internet

https://doi.org/10.1002/2211-5463.12725

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