Microenvironmental regulation by fibrillin-1.

Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has not been elucidated, even though the concept that fibrillin-1 provides extracellular control of growth factor signaling is curre...

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Bibliographic Details
Main Authors: Gerhard Sengle, Ko Tsutsui, Douglas R Keene, Sara F Tufa, Eric J Carlson, Noe L Charbonneau, Robert N Ono, Takako Sasaki, Mary K Wirtz, John R Samples, Liselotte I Fessler, John H Fessler, Kiyotoshi Sekiguchi, Susan J Hayflick, Lynn Y Sakai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3252277?pdf=render