A Simple Approximation to Bias in Gene–Environment Interaction Estimates When a Case Might Not Be the Case

Case–control genetic association studies are often used to examine the role of the genetic basis in complex diseases, such as cancer and neurodegenerative diseases. The role of the genetic basis might vary by nongenetic (environmental) measures, what is traditionally defined as gene–environment inte...

Full description

Bibliographic Details
Main Authors: Iryna Lobach, Inyoung Kim, Alexander Alekseyenko, Siarhei Lobach, Li Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00886/full