A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.

Bibliographic Details
Main Authors: Marc Fahrner, Michael Stadlbauer, Martin Muik, Petr Rathner, Peter Stathopulos, Mitsu Ikura, Norbert Müller, Christoph Romanin
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03062-w

Internet

https://doi.org/10.1038/s41467-018-03062-w

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