Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring

Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring

Prenatal exposure to maternal high-fat diet (mHFD) acts as a risk factor for various neurodevelopmental alterations in the progeny. Recent studies in mice revealed that mHFD results in both neuroinflammation and hypomyelination in the exposed offspring. Microglia, the brain-resident macrophages, pla...

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Bibliographic Details
Main Authors: Maude Bordeleau, PhD, Lourdes Fernández de Cossío, PhD, Chloé Lacabanne, PhD, Julie C. Savage, PhD, Nathalie Vernoux, PhD, Mallar Chakravarty, PhD, Marie-Ève Tremblay, PhD
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Maternal high-fat diet
Myelin
Cytosolic channels
Oligodendrocytes
Microglia
Adolescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354621000843

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http://www.sciencedirect.com/science/article/pii/S2666354621000843

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