Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes
The anti-diabetic properties of an inositol-enriched beverage (IEB) on the endothelial function and redox status in diabetic subjects were assessed. This was a 12-week, double-blind randomized controlled trial employing thirty-eight diabetic subjects that were divided into two intervention groups: o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464615004107 |
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doaj-f3c0954459c24484987403976aca880a |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Antonio Hernández-Mijares Celia Bañuls Susana Rovira-Llopis Ángeles Álvarez Samuel Orden Olalla Rubio-Puchol Víctor M. Víctor Milagros Rocha |
| spellingShingle |
Antonio Hernández-Mijares Celia Bañuls Susana Rovira-Llopis Ángeles Álvarez Samuel Orden Olalla Rubio-Puchol Víctor M. Víctor Milagros Rocha Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes Journal of Functional Foods Type 2 diabetes Inositol Inflammation Endothelial function Oxidative stress |
| author_facet |
Antonio Hernández-Mijares Celia Bañuls Susana Rovira-Llopis Ángeles Álvarez Samuel Orden Olalla Rubio-Puchol Víctor M. Víctor Milagros Rocha |
| author_sort |
Antonio Hernández-Mijares |
| title |
Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes |
| title_short |
Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes |
| title_full |
Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes |
| title_fullStr |
Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes |
| title_full_unstemmed |
Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes |
| title_sort |
chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes |
| publisher |
Elsevier |
| series |
Journal of Functional Foods |
| issn |
1756-4646 |
| publishDate |
2015-10-01 |
| description |
The anti-diabetic properties of an inositol-enriched beverage (IEB) on the endothelial function and redox status in diabetic subjects were assessed. This was a 12-week, double-blind randomized controlled trial employing thirty-eight diabetic subjects that were divided into two intervention groups: one receiving an IEB and the other a sucrose-enriched beverage. Subjects consuming IEB exhibited a significant decrease in triacylglycerol (8.82%) and HbA1c (4.53%) levels. Continuous glucose monitoring revealed a significant net reduction of 2.51 and 7.11% during postprandial and overnight fasting periods after consumption of IEB, respectively. Moreover, IEB improved endothelial function by reducing P-selectin levels and leucocyte–endothelium interactions, as there was an increase in rolling velocity and a reduction in polymorphonuclear leucocyte adhesion and induced a significant diminution in the generation of ROS. The present results show that IEB supplementation induces a significant improvement in glycaemic control in diabetic subjects by improving endothelial function and intracellular redox status. |
| topic |
Type 2 diabetes Inositol Inflammation Endothelial function Oxidative stress |
| url |
http://www.sciencedirect.com/science/article/pii/S1756464615004107 |
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doaj-f3c0954459c24484987403976aca880a2021-04-29T04:45:12ZengElsevierJournal of Functional Foods1756-46462015-10-0118598607Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetesAntonio Hernández-Mijares0Celia Bañuls1Susana Rovira-Llopis2Ángeles Álvarez3Samuel Orden4Olalla Rubio-Puchol5Víctor M. Víctor6Milagros Rocha7Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; Department of Medicine, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Corresponding authors. FISABIO-University Hospital Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain. Tel.: +34 961622492; fax: +34 961622492.Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, SpainFoundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, SpainCIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Department of Pharmacology, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, SpainCIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Department of Pharmacology, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, SpainService of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, SpainFoundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Department of Physiology, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Corresponding authors. FISABIO-University Hospital Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain. Tel.: +34 961622492; fax: +34 961622492.Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Corresponding authors. FISABIO-University Hospital Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain. Tel.: +34 961622492; fax: +34 961622492.The anti-diabetic properties of an inositol-enriched beverage (IEB) on the endothelial function and redox status in diabetic subjects were assessed. This was a 12-week, double-blind randomized controlled trial employing thirty-eight diabetic subjects that were divided into two intervention groups: one receiving an IEB and the other a sucrose-enriched beverage. Subjects consuming IEB exhibited a significant decrease in triacylglycerol (8.82%) and HbA1c (4.53%) levels. Continuous glucose monitoring revealed a significant net reduction of 2.51 and 7.11% during postprandial and overnight fasting periods after consumption of IEB, respectively. Moreover, IEB improved endothelial function by reducing P-selectin levels and leucocyte–endothelium interactions, as there was an increase in rolling velocity and a reduction in polymorphonuclear leucocyte adhesion and induced a significant diminution in the generation of ROS. The present results show that IEB supplementation induces a significant improvement in glycaemic control in diabetic subjects by improving endothelial function and intracellular redox status.http://www.sciencedirect.com/science/article/pii/S1756464615004107Type 2 diabetesInositolInflammationEndothelial functionOxidative stress |