Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma

Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma

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In order to investigate signal transduction and activation of transcription 3 (STAT3) signaling on angiogenesis in colorectal carcinoma (CRC) after inhibiting STAT3 expression, we constructed the HT-29-shSTAT3 cell line by lentivirus-mediated RNAi. Cell growth was assessed with MTT and the cell cycl...

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Bibliographic Details
Main Authors: W.F. Qian, W.X. Guan, Y. Gao, J.F. Tan, Z.M. Qiao, H. Huang, C.L. Xia
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
STAT3
RNA interference
Colorectal carcinoma
Angiogenesis
VEGFA
MMP2
FGF2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200005

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200005

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