DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers

DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers

Cancer genomes harbor numerous genomic alterations and many cancers accumulate thousands of nucleotide sequence variations. A prominent fraction of these mutations arises as a consequence of the off-target activity of DNA/RNA editing cytosine deaminases followed by the replication/repair of edited s...

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Bibliographic Details
Main Authors: Igor B. Rogozin, Abiel Roche-Lima, Kathrin Tyryshkin, Kelvin Carrasquillo-Carrión, Artem G. Lada, Lennard Y. Poliakov, Elena Schwartz, Andreu Saura, Vyacheslav Yurchenko, David N. Cooper, Anna R. Panchenko, Youri I. Pavlov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Genetics
Subjects:
tumor cells
frequency matrices
database
computational biology
somatic hypermutation
immunoglobulin genes
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.671866/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.671866/full

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