A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.

A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.

Gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) establish lifelong latency in their hosts and are associated with the development of several types of malignancies, including a subset of B cell lymphomas. These viruses are thought to...

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Bibliographic Details
Main Authors: Carrie B Coleman, Jennifer E McGraw, Emily R Feldman, Alexa N Roth, Lisa R Keyes, Katrina R Grau, Stephanie L Cochran, Thomas J Waldschmidt, Chengyu Liang, J Craig Forrest, Scott A Tibbetts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3916410?pdf=render

Internet

http://europepmc.org/articles/PMC3916410?pdf=render

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