Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic pain.

Chronic, intractable pain is a problem of pandemic proportions. Pain caused by nerve injuries (neuropathic pain) is extremely difficult to treat. For centuries, opiates such as morphine have been the first-line treatment for severe chronic pain. However, opiates are often ineffective against neuropa...

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Bibliographic Details
Main Authors: Courtney L Donica, Yan Cui, Shanping Shi, Howard B Gutstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4018247?pdf=render